Aim:
To determine clinical efficacy of developed therapeutic and prophylactic complex (TPC) in orthodontic patients with periodontal pathology and studying its correction after installation of fixed orthodontic appliances. Evaluation of this efficacy will be based on assessment of periodontal indices and changes in activity of enzymes of antioxidant defense, as well as the activity of enzymatic markers of local stress response in oral fluid.

Material and methods:
118 patients with orthodontic anomalies and generalized periodontitis were divided into two groups: 60 (main), and 58 (comparison). Clinical and paraclinical parameters for assessing periodontal health, including biochemical parameters of enzymes of oral fluid, were studied. In main group, TPС was applied, and in comparison group, traditional treatment regimen was used. The indicators were evaluated before and after periodontal treatment.

Results:
The developed TPC made it possible reducing by 3-3.5 times the preparation for active orthodontic period and achieve stabilization of pathological process in the periodontal tissues at different time after braces installation. In patients of main group, indicators of studied enzymes in oral fluid were improved by 1.5-2.4 times, compared to results obtained in comparison group, where, after using traditional treatment regimen, level of oxidative stress and local oxidative metabolic disorders remained high.

Conclusions:
Changes in in periodontal status and activity of SOD and LDH activity relative to CA and AA measured in orthodontic patients with periodontal disease were shown to be important biomarkers of treatment effectiveness and controlling the state of reduced periodontium comparing to background of oxidative stress caused by fixed orthodontic appliances.