Aim: To evaluate the performance of ChatGPT-4o in creating personalized physical rehabilitation plans for comorbid patients. Materials and Methods: ChatGPT-4o was employed to generate physical rehabilitation plans for 50 clinical cases of comorbid patients. These plans were evaluated independently by two experts according to 6 criteria using a 5-point Likert scale. Experts also classified each plan regarding its suitability for use into 3 categories: “Completely unsuitable for use”, “Suitable for use with corrections”, “Completely suitable for use”. Statistical analysis included the Mann–Whitney U test, intraclass correlation coefficient (ICC) and linear weighted Cohen's kappa (kw). The statistical significance was set at p<0.05 Results: The overall mean score of ChatGPT-4o generated rehabilitation plans was 4.30±0.28 with the highest scores for respiratory and musculoskeletal pathology (4.37±0.36 and 4.33±0.24, respectively). Among the evaluation criteria, the highest indicators were observed for Clinical accuracy and Safety (4.59±0.59 and 4.41±0.71, respectively). 72.00% of the generated plans were classified as “Suitable for use with corrections”. None of the plans were identified as “Completely unsuitable for use”. The agreement percentage ranged from 84% to 90%, ICC values were 0.80-0.86, and overall suitability kw was 0.77 Conclusions: LLM-generated rehabilitation plans show promise as supportive tools in clinical practice, but they are not yet at a stage where they can be implemented without expert review and modification. The high overall inter-rater reliability provides confidence in the evaluation process, while also highlighting areas for improvement in both the LLM's performance and the assessment methodology.