Aims: This review analyzes and deepens our understanding of the anatomical variations of the hepatopancreatic region, a crucial area in many medical fields. Precision and surgical efficiency largely rely on a thorough understanding of anatomical nuances and variations. In recent years, significant emphasis has been placed on exploring anatomical variations, particularly in the context of hepatopancreatic surgery. Material and methods: This review collects key information on the types of lesions within the major vessels of the liver and pancreas and presents their incidence. The cited material is based on a review of studies and observations, textbooks, and other review articles. Conclusions: The collected data highlight the importance of hepatic and pancreatic vascular variability, which should be considered an anatomical feature rather than an exception. Further exploration of the occurrence of such features is crucial. This understanding of anatomy is particularly crucial in hepatobiliary and pancreatic surgery, where anatomical complexity directly impacts procedural planning and surgical strategy.