Aim:
Background: Azole derivatives have emerged as a significant class of compounds in medicinal chemistry due to their diverse biological activities. These compounds have demonstrated efficacy against a broad range of infections, including bacterial, fungal, malarial, and viral infections. Aims: This research paper investigates the synthesis and antibacterial activity of novel azole derivatives incorporating Etodolac.

Material and methods:
Materials and methods: The study focused on the reaction of Etodolac with three different aromatic amines: o-phenylene diamine, 2-aminophenol, and 2-aminothiophenol, resulting in three new compounds (1-3). The antibacterial activity of these compounds was assessed against Escherichia coli, Klebsiella, Staphylococcus aureus, and Streptococcus mutans.

Results:
Results: Compound 1 demonstrated the most potent antimicrobial activity against all four bacteria, exhibiting a remarkably low MIC against Escherichia coli.

Conclusions:
Conclusion: The results of this research suggest that incorporating Etodolac into the synthesis of azole derivatives can lead to potent antimicrobial agents. Further exploration of these compounds is warranted to fully understand their potential therapeutic applications.