Aim:
Introduction and objectives: Hypertension (HTN) is a chronic condition linked to cardiovascular disease (CVD). Early biomarkers are essential for risk assessment. The current study aimed to predict CVD as a complication in HTN by identifying the CGRP, lipid profile, and atherogenic indices. Methods: Fifty-four male HTN patients and 45 healthy controls (ages 51–69) were

Material and methods:
enrolled. The subjects were divided into two subgroups according to LAP: Group 1 was HTN patients with LAP (≤50), and Group 2 was HTN patients with LAP >50. Serum CGRP (pg/mL) was measured via ELISA; lipid profiles and atherogenic indices were assessed spectrophotometrically. Results:There was a significant increase in the mean of WHR, VAI, LAP,

Results:
SBP, DBP, atherogenic indices, and lipid profile in the HTN groups compared to the control group, except CGRP and HDL-C showed a significant decrease (P< 0.001). The G2 group showed a significant decrease in CGRP levels compared to the G1 group. The relation between CGRP and CVD remained significant after adjusting for major risk factors in a multivariate analysis. ROC

Conclusions:
curve based on CGRP levels to indicate the existence of CVD in HTN patients was 0.80. Reduced CGRP levels are associated with increased cardiovascular risk in hypertensive patients and may serve as a promising early biomarker. In addition, the AUC of CGRP was 0.82 in patients with a LAP greater than 50 compared to those with a LAP less than 50. Conclusion:These findings support CGRP’s potential role in CVD risk stratification and targeted management.