Aim: To present theoretical and practical approaches to the development of digital competence among participants in the medical education environment based on the digitalization of Ukraine’s healthcare system. Materials and Methods: To achieve the research objective, general scientific theoretical and empirical methods were used, including: bibliosemantic method, system analysis method, conversations and interviews with participants in the educational process, modeling of the process of formation of digital competence. Results: An analysis of self-assessment and the level of digital competence formation among healthcare representatives helped determine the criteria for updating educational programs on digital competence development as a result, steps were taken to introduce comprehensive training in digital competencies, covering previously unaddressed aspects and enabling healthcare professionals to acquire all necessary competencies. Therefore, we presented a model illus trating the interrelation of competency formation and learning outcomes (LOs) through the lens of qualification characteristics and higher education standards for the specialty, interpreted in the information-educational environment model NMU_DIGITAL. Conclusions: Medical and pharmaceutical education must adapt to modern standards and tools, regardless of whether they relate to treatment, prevention, rehabilitation, or management activities. Developing digital competence and using digital tools should begin at the earliest stages of professional orientation, be thoroughly studied at the pre-higher and higher education levels, and continue through lifelong professional development.