Aim: To determine the main approaches to forming principles of academic integrity and motivating higher education students in medical higher education institutions. Materials and Methods: The study combines quantitative and qualitative methods and was conducted at the Bogomolets National Medical University, Kyiv, Ukraine, in 2024. During the research process, a complex of general scientific and specialized methods was applied. In particular, the logical-analytical method was used to structure information and identify cause-and-effect relationships. Theoretical-logical analysis allowed for the formulation of theoretical propositions and hypotheses. Comparative analysis was applied to compare different approaches and concepts. Quantitative sociological methods, including the collection, systematization, and statistical analysis of information, were used to process empirical data. The method of formalization and generalization facilitated the formulation of conclusions based on the results obtained. The object of the study is medical education students at Bogomolets NMU (N=233). The study involved students of the second master’s level (N=172), students of the third educational-scientific level (N=12), and students of professional pre-higher education (N=49), the vast majority of whom are full-time students (N=215). Statistical data processing was performed using the IBM SPSS Statistics software package. Results: Adherence to academic integrity is an important component of knowledge transfer. Honest teaching, documenting, and disseminating research results contribute to the understanding of information and knowledge between scientists, students, and the public. All these factors improve the quality of higher education and the development of scientific research. Adherence to academic integrity is an important responsibility for every participant in the educational process and contributes to the creation of an honest and progressive academic environment. With the increasing use of AI, more and more questions arise regarding the mechanisms of its correct use and the strengthening of control over compliance with the principles of academic integrity. Conclusions: Adherence to the principles of academic integrity serves as a key motivator for students and faculty in the context of complying with academic standards. In this regard, a relevant area of scientific research is the development of a methodology for studying the phenomenon of academic integrity in higher medical education institutions. The proposed methodology involves an empirical study of the attitudes of participants in the educational process towards fundamental value orientations, which will provide objective data for further analysis and the development of practical recommendations