Reproductive Physiological Amelioration of BPA-Induced Toxicity by Resveratrol: Sperm Quality Preservation, DNA Damage Mitigation, and Testicular Protection
1
Department of Pharmacology, College of Pharmacy, University of Al Kafeel, Najaf, Iraq, Iraq
2
Department of pharmaceutics, School of pharmacy, AlSafwa University College, Iraq, Iraq
3
Pharmacognosy Department, College of Pharmacy, The Islamic University in Najaf, Najaf, Iraq, Iraq
Submission date: 2025-05-02
Final revision date: 2025-07-21
Acceptance date: 2025-10-13
Publication date: 2025-11-30
Corresponding author
Mohamed A. Zarka
Pharmacognosy Department, College of Pharmacy, The Islamic University in Najaf, Najaf, Iraq, Iraq
Pharmacognosy Department, College of Pharmacy, The Islamic University in Najaf, Najaf, Iraq, Iraq
Wiadomości Lekarskie 2025;(11):2286-2296
KEYWORDS
TOPICS
ABSTRACT
Aim:
Aims: The object of the present study aimed to investigate the impact of Bisphenol A on the fragmentation, and histopathological changes, and evaluating the protective effects of resveratrol against Bisphenol A.
Material and methods:
Material and Methods: The study used forty adults male Wistar rats were that randomly divided into four groups: a control group, a Bisphenol A group administered at 50 mg/kg/day, a resveratrol group at 50 mg/kg/day, and a Bisphenol + resveratrol group at the same dosages for 60 consecutive days. The blood and tissue samples were collected for evaluating the sperm parameters, DNA integrity, Luteinizing hormone, Testosterone hormone, total antioxidant capacity, and histopathological section.
Results:
Results: The results showed that Bisphenol A exposure causes significantly disrupted in sperm motility, concentration, morphology, and DNA integrity, with severe histopathological change in testicular tissue and causes significantly increasing in luteinizing hormone and decreased testosterone levels. In contrast, the results illustrated the resveratrol play as protective effects by conserved the sperm quality, testicular histopathology and reducing DNA fragmentation.
Conclusions:
Conclusion: The Bisphenol A-induced significantly increased in oxidative stress while resveratrol play significant protection against Bisphenol A which that induced testicular damage. The present finds proved that resveratrol is a potential therapeutic agent that can be used as an intervention against chemical substances in the environment and preserve the fertility
Aims: The object of the present study aimed to investigate the impact of Bisphenol A on the fragmentation, and histopathological changes, and evaluating the protective effects of resveratrol against Bisphenol A.
Material and methods:
Material and Methods: The study used forty adults male Wistar rats were that randomly divided into four groups: a control group, a Bisphenol A group administered at 50 mg/kg/day, a resveratrol group at 50 mg/kg/day, and a Bisphenol + resveratrol group at the same dosages for 60 consecutive days. The blood and tissue samples were collected for evaluating the sperm parameters, DNA integrity, Luteinizing hormone, Testosterone hormone, total antioxidant capacity, and histopathological section.
Results:
Results: The results showed that Bisphenol A exposure causes significantly disrupted in sperm motility, concentration, morphology, and DNA integrity, with severe histopathological change in testicular tissue and causes significantly increasing in luteinizing hormone and decreased testosterone levels. In contrast, the results illustrated the resveratrol play as protective effects by conserved the sperm quality, testicular histopathology and reducing DNA fragmentation.
Conclusions:
Conclusion: The Bisphenol A-induced significantly increased in oxidative stress while resveratrol play significant protection against Bisphenol A which that induced testicular damage. The present finds proved that resveratrol is a potential therapeutic agent that can be used as an intervention against chemical substances in the environment and preserve the fertility
| eISSN: | 2719-342X |
| ISSN: | 0043-5147 |
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