Serological Detection of Measles Virus in Association with IL-10 and IL-17 Levels in Aborted Women
1
Department of Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar 64001, Iraq, Iraq
2
Department of Obstetrics and Gynecology, College of Medicine, University of Thi-Qar, 64001, Iraq, Iraq
Submission date: 2025-06-04
Final revision date: 2025-10-14
Acceptance date: 2026-01-12
Publication date: 2026-01-30
Corresponding author
Mohammed Jasim Mohammed Shallal
Department of Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar 64001, Iraq, Iraq
Department of Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar 64001, Iraq, Iraq
Wiadomości Lekarskie 2026;(1):38-45
KEYWORDS
TOPICS
ABSTRACT
Aim:
Background: Measles (rubeola) is a highly infectious respiratory ailment caused by a single-stranded, enveloped RNA virus from the genus Morbillivirus in the Paramyxoviridae family. Aim: To investigate immunological markers that may be associated with measles viral infections in aborted women, specifically cytokines IL-10 and IL-17.
Material and methods:
Materials and methods: From October 2024 to the end of December 2024, the study included 352 participants, comprising 176 females with a history of abortions and 176 females with normal pregnancies, who acted as a control group. Serum samples were analyzed for IL-10 and IL-17 using the enzyme-linked immunosorbent assay (ELISA) method.
Results:
Results: The serum level of IL-10 was significantly lower in women with abortion compared to the control group, with a median of 216.02 pg/ml versus 329.79 pg/ml, respectively (p<0.001). Similarly, the serum level of IL-17 was significantly higher in women with abortion compared to the control group, with a median of 85.24 pg/ml versus 51.76 pg/ml, respectively p<0.001).
Conclusions:
Conclusions: The main clinical features of a viral infection, such as measles, during pregnancy are fever. Correlation of IL-10 and IL-17 to measles infection in the control group: Measles IgM and IgG showed no significant correlation to IL-10 and IL-17 (p>0.05). In the abortion group, measles IgM and IgG showed significant positive correlation to IL-10 and IL-17 p<0.001, finally, family history is a significant risk factor for abortion.
Background: Measles (rubeola) is a highly infectious respiratory ailment caused by a single-stranded, enveloped RNA virus from the genus Morbillivirus in the Paramyxoviridae family. Aim: To investigate immunological markers that may be associated with measles viral infections in aborted women, specifically cytokines IL-10 and IL-17.
Material and methods:
Materials and methods: From October 2024 to the end of December 2024, the study included 352 participants, comprising 176 females with a history of abortions and 176 females with normal pregnancies, who acted as a control group. Serum samples were analyzed for IL-10 and IL-17 using the enzyme-linked immunosorbent assay (ELISA) method.
Results:
Results: The serum level of IL-10 was significantly lower in women with abortion compared to the control group, with a median of 216.02 pg/ml versus 329.79 pg/ml, respectively (p<0.001). Similarly, the serum level of IL-17 was significantly higher in women with abortion compared to the control group, with a median of 85.24 pg/ml versus 51.76 pg/ml, respectively p<0.001).
Conclusions:
Conclusions: The main clinical features of a viral infection, such as measles, during pregnancy are fever. Correlation of IL-10 and IL-17 to measles infection in the control group: Measles IgM and IgG showed no significant correlation to IL-10 and IL-17 (p>0.05). In the abortion group, measles IgM and IgG showed significant positive correlation to IL-10 and IL-17 p<0.001, finally, family history is a significant risk factor for abortion.
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| eISSN: | 2719-342X |
| ISSN: | 0043-5147 |
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