Aim: The objective of the study was to establish the most important socioeconomic and clinical predictors of coping mechanisms among mothers when their child was admitted to the hospital in Iraq. Materials and Methods: The study was a descriptive and cross-sectional study carried out in the pediatric wards of Basrah between September 2025 and January 2026. One hundred mothers were recruited. The Sociodemographic/clinical sheet was used to collect data in the form of a Sociodemographic/clinical sheet and the Arabic Brief COPE Inventory. Descriptive statistics, correlation, ANOVA and multiple regression analysis were conducted to determine predictors. Results: Regression analysis revealed that maternal coping was significantly predicted by higher education level (β=0.38, p<0.001), higher socioeconomic status (β=0.32, p<0.001), being employed (β=0.25, p=0.006), a shorter hospital stay (β=-0.21, p=0.013), and acute rather than chronic diagnosis (β=-0.24, p=0.008). The model explained 52% of variance in coping (R²=0.52, p<0.001). Conclusions: Modifiable socioeconomic factors significantly predict maternal coping in the hospitalization of a child. To increase caregiver resilience, screening and support programs related to these predictors should be implemented into the healthcare systems.