The structure of the Poltava region population, determined by the polymorphisms rs3745274 and rs1799971 significant in the kinetics of anaesthetics
1
Department of anesthesiology and intensive care, Poltava Regional Clinical Oncology Dispensary, Ukraine
2
Department of Anesthesiology and Intensive Care, Poltava State Medical University, Ukraine
3
Research Institute of Genetic and Immunological Basis of Development of Pathology and Pharmacogenetics, Poltava State Medical University, Ukraine
Submission date: 2026-01-13
Acceptance date: 2026-07-15
Publication date: 2026-09-30
Corresponding author
Kostiantyn Volodymyrovych Tarasenko
Department of Anesthesiology and Intensive Care, Poltava State Medical University, Shevchenko Str., 23, 36011, Poltava, Ukraine
Department of Anesthesiology and Intensive Care, Poltava State Medical University, Shevchenko Str., 23, 36011, Poltava, Ukraine
Wiadomości Lekarskie 2026;(9):2152-2157
KEYWORDS
TOPICS
ABSTRACT
Aim:
To determine the population structure of the Poltava region by the significant SNPs rs3745274 and rs1799971 of the CYP2B6 and OPRM1 genes in the kinetics of anesthetics.
Material and methods:
The study involved 106 people: 51 patients with oncological pathology of the gastrointestinal tract and 55 people in the control group. Genotyping of SNPs rs3745274 and rs1799971 in the CYP2B6 and OPRM1 genes was performed by the polymerase chain reaction method with determination of the length of restriction fragments. Statistical analysis of the data was performed using the GenAlEx population genetic analysis package.
Results:
The frequencies of allelic variants and genotypes of the CYP2B6 (c.516G>T) and OPRM1 (c.118A>G) genes are close to the corresponding indicators in the Ukrainian and other European populations. The statistically significant difference in expected genotype frequencies (p≤0.05) between the patient and control groups for the SNPs of the CYP2B6 gene (c.516G>T) is obviously related to the clinical features of the patient sample.
Conclusions:
The identified genetic polymorphism of the population of the Poltava region for the CYP2B6 (c.516G>T) and OPRM1 (c.118A>G) genes may be a pharmacogenetic basis for personalized anesthetics.
To determine the population structure of the Poltava region by the significant SNPs rs3745274 and rs1799971 of the CYP2B6 and OPRM1 genes in the kinetics of anesthetics.
Material and methods:
The study involved 106 people: 51 patients with oncological pathology of the gastrointestinal tract and 55 people in the control group. Genotyping of SNPs rs3745274 and rs1799971 in the CYP2B6 and OPRM1 genes was performed by the polymerase chain reaction method with determination of the length of restriction fragments. Statistical analysis of the data was performed using the GenAlEx population genetic analysis package.
Results:
The frequencies of allelic variants and genotypes of the CYP2B6 (c.516G>T) and OPRM1 (c.118A>G) genes are close to the corresponding indicators in the Ukrainian and other European populations. The statistically significant difference in expected genotype frequencies (p≤0.05) between the patient and control groups for the SNPs of the CYP2B6 gene (c.516G>T) is obviously related to the clinical features of the patient sample.
Conclusions:
The identified genetic polymorphism of the population of the Poltava region for the CYP2B6 (c.516G>T) and OPRM1 (c.118A>G) genes may be a pharmacogenetic basis for personalized anesthetics.
| eISSN: | 2719-342X |
| ISSN: | 0043-5147 |
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