Aim:
Diabetes mellitus will soon approaches half a billion globally, work to decrease morbidity and mortality is going on massively, the rule of inflammation and inflammatory markers and mediators is well established regarding the initiation and progression of diseases, Soluble Vascular Cell Adhesion Molecule -1 (sVACAM-1) is one of the inflammatory proteins that increases endothelial damage by cellular recruitment endothelium This study aimed to assess the Association of sVACAM-1 with type 2 diabetes mellitus and the impact of Cardiovascular Disease and Glycemic Control on its level.

Material and methods:
This is a study of sVACAM-1 level in 57 patient with type 2 Diabetes mellitus in Al-Najaf/Iraq in comparison with normal control, the level of sVACAM-1 was analyzed also according to parameters of age , sex, smoking, body mass index(BMI),presence of systemic hypertension and cardiovascular diseases (ischemic heart disease and heart failure), Poor diabetic control (Hemoglobin A1C ≥7) and the mean of 2 days postprandial blood sugar

Results:
All parameters except smoking were associated with higher levels of sVACAM-1, however the differences weren’t significant statistically, there was no linear correlation between the mean 2 days post prandial blood sugar and sVACAM-1

Conclusions:
sVACAM-1 is important to be assessed in diabetic patients and recommended to establish cutoff values of normality