Aim: To improve early diagnosis by analyzing the pathological pattern of "mother-newborn" in newborns. Materials and Methods: The study group included newborns with a diagnosis of “Infection specific to the perinatal period, unspecified” (P39,9, n=64), born to mothers (age 31,31 ± 2,08 years) with a complicated diagnosis and a control group (n=31) of infants. Results: Clinical manifestations in newborns mainly included involvement of the central nervous system (57,8%), cardiovascular system (12,0%), congenital heart defects (2,8%), jaundice (11,0%), hepatosplenomegaly (5,2%), exanthema (9,0%), hypothermia (70,6%). Markers of inflammatory response confirmed an increase in the level of IL-1, a significant increase in IL-6 levels, the level of IL-8 in the studied contingent also significantly differs from the data of the control group, the level γ-IFN also exceeded the reference values by 2,4 times. Hypoxic-ischemic encephalopathy was detected in 63 infants (57,8%) and intracranial hemorrhage was diagnosed in 25 (22,9%) infants. Conclusions: The values of cytokine profile parameters (IL-1, IL-6, IL-8, IL-10) on the first day of life varied within the reference values, but with significant differences from the values of the control group, which were 9,24; 20; 11 times, respectively. The levels of inflammatory mediators (γ-IFN, procalcitonin, neopterin, TNF-α, Pg E2) significantly differed from the data of the control group and exceeded the upper limit of reference values by 2,4; 40; 8,9; 25; 3,5 times, respectively.