Effect of certain immunological markers on the level of anti-Müllerian hormone (AMH) in women infected with Toxoplasma gondii: further investigations
1
Department of Biology, Faculty of Science, University of Kufa, Iraq, Iraq
2
Faculty of Pharmacy, University of Kufa, Najaf, Iraq, Iraq
3
College of Pharmacy, University of Alkafeel, Al-Najaf, Iraq, Iraq
Submission date: 2025-07-01
Acceptance date: 2025-11-23
Publication date: 2025-12-30
Wiadomości Lekarskie 2025;(12):2669-2676
KEYWORDS
TOPICS
ABSTRACT
Aim:
The aim of the present study is to explore the effects of T. gondii on immune levels and try to find out correlations that maybe manifest later on women who have had the infection and to assess the direct relationship between the infection and a rise in the value of anti-Müllerian hormone (AMH).
Material and methods:
Blood samples were collected from two identical groups of 80 (40 healthy control and 40 infected with T. gondii). The participants were women at an age ranging from 20 to 25 years; Group 1, healthy women who were not infected with Toxoplasma comprised the control series; Group 2, women who were Toxoplasma-infected and who visited medical facilities. Toxoplasma infection was diagnosed using the Latex Agglutination Test (LAT). Serum human interleukins (IL-1β and IL-6), tumor necrosis factor alpha (TNF-α) and anti-Müllerian hormone (AMH) were detected by Enzyme Linked Immunosorbent Assay (ELISA) method.
Results:
Compared with the control group, infected women had significantly higher levels of human IL-1 β, IL-6, and tumor necrosis factor alpha (TNF-α). AMH concentrations correlated significantly in a positive manner with human IL-1β, IL-6, and tumor necrosis factor alpha (TNF-α).
Conclusions:
Three immune parameters (IL-1 β, IL-6, and TNF-α) had elevated circulating levels, which implied the strong association between AMH and these immune variables.
The aim of the present study is to explore the effects of T. gondii on immune levels and try to find out correlations that maybe manifest later on women who have had the infection and to assess the direct relationship between the infection and a rise in the value of anti-Müllerian hormone (AMH).
Material and methods:
Blood samples were collected from two identical groups of 80 (40 healthy control and 40 infected with T. gondii). The participants were women at an age ranging from 20 to 25 years; Group 1, healthy women who were not infected with Toxoplasma comprised the control series; Group 2, women who were Toxoplasma-infected and who visited medical facilities. Toxoplasma infection was diagnosed using the Latex Agglutination Test (LAT). Serum human interleukins (IL-1β and IL-6), tumor necrosis factor alpha (TNF-α) and anti-Müllerian hormone (AMH) were detected by Enzyme Linked Immunosorbent Assay (ELISA) method.
Results:
Compared with the control group, infected women had significantly higher levels of human IL-1 β, IL-6, and tumor necrosis factor alpha (TNF-α). AMH concentrations correlated significantly in a positive manner with human IL-1β, IL-6, and tumor necrosis factor alpha (TNF-α).
Conclusions:
Three immune parameters (IL-1 β, IL-6, and TNF-α) had elevated circulating levels, which implied the strong association between AMH and these immune variables.
| eISSN: | 2719-342X |
| ISSN: | 0043-5147 |
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