Aim: Investigate the effectiveness of micellar foam containing tea tree oil and Roman chamomile oil in preoperative eyelid sanitation in patients with blepharitis. Materials and Methods: The study involved 37 patients with blepharitis, aged 28-62. Patients were split into two groups: 22 who used micellar foam preoperatively and 15 who did not. Diagnoses included chronic, seborrheic, and demodicosis blepharitis. Symptoms and signs were monitored over a ten-day treatment period, showing varied responses to micellar foam. Results: The study showed a significant improvement in blepharitis symptoms with the use of foam containing tea tree and Roman chamomile oils. Patients reported reduced dryness, scaling, hyperemia, and itching. Microscopic examination showed disappearance of scales and couplings, and reduced hyperemia. Bacterial contamination decreased significantly, with good tolerance to the treatment. Conclusions: Recent literature and our study indicate that women predominantly suffer from blepharitis, possibly due to their higher medical service utilization. Most cases were mild to moderate, with multifactorial causes and bacterial influence. Eight patients (36.4%) had non-bacterial blepharitis. Understanding blepharitis epidemiology helps in pathogenetically targeted treatment. The innovative micellar foam with tea tree oil and chamomile shows positive results and reduces antibiotic resistance risks.