The aim: Conducting a scientific analysis of domestic and foreign sources of information regarding modern conceptual views diagnostic and effectiveness of kidney transplantation in Lupus Nephritis. Materials and metods: Used methods of historical-bibliographic and systematic approach. The search for literary sources was carried out in four main scientific databases: Google Scholar, PubMed, The review included original articles, research, and official recommendations from medical associations. Conclusions: Scientific analysis confirmed better survival rates and a lower complication rate compared to hemodialysis and peritoneal dialysis. Survival rates for kidney transplantation over 5 to 10 years are comparable to those for patients with other diseases. Identifying new serological and immunological markers is crucial for the early diagnosis and prevention of acute kidney damage and subsequent graft loss. The frequency and features of the course of recurrent lupus nephritis after kidney transplantation were determined. KEY WORDS: effectiveness, lupus-nephritis, kidney transplantation, modern biomarkers.