Effectiveness of rifaximin and probiotics for the correction of intestinal permeability in patients with metabolic-associated fatty liver disease in combination with type 2 diabetes mellitus
 
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Department of Internal Medicine №1, Bogomolets National Medical University, Ukraine
 
 
Submission date: 2023-08-10
 
 
Acceptance date: 2024-02-27
 
 
Publication date: 2024-07-06
 
 
Corresponding author
Olga Kostiantynivna Didyk   

Department of Internal Medicine №1, Bogomolets National Medical University, 13 T. Shevchenko blvd, 01601, Kyiv, Ukraine
 
 
Wiadomości Lekarskie 2024;(4)
 
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ABSTRACT
Aim:
The aim of the study was to investigate the effectiveness of rifaximin and probiotics for the correction of intestinal permeability in patients with metabolic-associated fatty liver disease (MAFLD) in combination with type 2 diabetes mellitus.

Material and methods:
The prospective interventional randomized investigation included 68 patients with MAFLD in combination with type 2 diabetes, who were examined and divided into the 2 groups of treatment.

Results:
The serum levels of interleukin (IL) - 6, IL-10 and zonulin, indicators of liver functional activity, liver attenuation coefficient between treatment group vs. control group after 2 weeks, 1 month, 3 and 6 months of therapy were significant differed. The serum levels of IL-6 and zonulin significantly decreasing and increasing of IL-10 in the treatment group after 2 weeks, 1, 3 and 6 months of combined therapy. When comparing of stool short-chain fatty acids concentration between treatment group vs. control group after 2 weeks, 1 month, 3 and 6 months of therapy the levels of acetic, butyric and propionic acids significantly differences and increase in their levels were established.

Conclusions:
The results of the study in dynamics during 6 months show that the additional appointment of rifaximin, multispecies probiotic and prebiotic to metformin in patients with MAFLD and type 2 diabetes led to the elimination of subclinical inflammation, modulation of the permeability of the intestinal barrier and lowering increased intestinal permeability, as well as to the lower serum activity of liver aminotransferases and decrease the stage of steatosis.

eISSN:2719-342X
ISSN:0043-5147
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