Aim: To evaluate central haemodynamic parameters in the long-term period after inferior vena cava (IVC) thrombosis depending on the treatment method. Materials and Methods: Blood flow parameters were evaluated in 25 patients after IVC thrombosis. All patients formed the I (main) group. The results of the examination of patients in group I were compared with group II (control) consisting of 10 healthy individuals. Results: Open thromboectomy from the lumen of the IVC combined with incomplete mechanical cavaplication allows not only to restore the lumen of the venous trunk and prevent the development of pulmonary embolism, but also to quickly normalise the parameters of central and regional venous haemodynamics. Analysis of blood flow parameters in the early and late postoperative periods allows us to conclude that partial mechanical cavaplication does not impair venous return to the heart, and open thromboectomy prevents the development of post-thrombotic changes. Conservative treatment of IVC thrombosis accelerates recanalisation processes compared to the natural course of thrombosis, but during this time, natural venous collaterals develop, which ensure venous outflo from the lower half of the body and remain active even after restoration of the IVC lumen. Conclusions: Open thrombectomy of the inferior vena cava allows restoration of the lumen, ensuring effective venous blood flow, prevent post-thrombotic syndrome. Cavoplication prevents thromboembolic complications, increases blood flow velocity and leads to spontaneous restoration of the lumen of the inferior vena cava within 14.3±2.2 months (p.0.01).