Aim: This review explores the synergistic role of general practitioners and ophthalmologists in the prevention, detection, and management of diabetic reti nopathy, highlighting the importance of collaborative care between these specialties. Materials and Methods: A systematic literature review spanning 2014 to 2024 was conducted using databases such as PubMed, MEDLINE, Scopus, and the WHO. Studies selected included original research, reviews, and guidelines focusing on the collaborative roles of family physicians and ophthalmologists in managing diabetic retinopathy. Conclusions: Effective management of diabetic retinopathy necessitates close collaboration between general practitioners and ophthalmologists. General practitioners are vital in early detection and managing systemic risk factors like glucose and blood pressure, which are crucial for preventing retinopathy. Ophthalmologists play a critical role in diagnosing, monitoring, and treating retinal changes, ensuring timely intervention to prevent severe complications. This integrated approach significantly enhances patient outcomes, highlighting the need for coordinated care strategies in diabetic retinopathy management