Introduction Aim The aim of the study was to analyze the association of SNPrs2981579 FGFR2 gene as a risk factor for skeletal class II malocclusion in a Ukrainian population. Material and methods Genotyping of 103 patients from different regions of Ukraine diagnosed with of class II malocclusion was performed. The control group included 106 residents of Kyiv City without orthodontic pathologies and chronic diseases. The association of the T rs2981579 allele of the FGFR2 gene with the risk of developing of class II malocclusion was investigated (OR = 1.58, p = 0.02). Results The risk class II malocclusion in the control group did not depend on the allelic status of SNP rs2981579; the additive inheritance pattern showed that for heterozygotes (C/T) OR was 1.54, p = 0.01, for homozygotes for the variant allele (T/T) OR was 1.53, p = 0.01. Conclusions The SNP rs2981579 (C>T) of FGFR2 gene locus is a factor of increased susceptibility to the development of class II malocclusion in the Ukrainian population. Material and Methods Results Conclusions