Aim: To evaluate the morphological changes in the cornea in stromal opacification, revealed by a comparative analysis of the results of confocal microscopy and optical coherence tomography on the example of clinical cases of stromal keratitis. Materials and Methods: We examined 16 patients (20 eyes), including 7 men and 9 women aged 42 to 72 years. All patients underwent a standard oph thalmologic examination. Results: In 95% of cases (19 eyes), there was an impoverishment of the nerve fibers of the subbasal nerve plexus (SNP), their thinning and change in con figuration. The AS-OCT images showed in all cases (100%) a higher reflexivity of the posterior stroma in the area. In 61.5% (16 eyes), there was a decrease in corneal thickness due to stromal thinning and the appearance of a demarcation zone. Conclusions: Confocal microscopy and optical coherence tomography have diagnostic value for determining the structural organization, thickness, shape of the cornea, its changes, and to assess the effectiveness of treatment.