Introduction: Holter monitoring is an essential tool in modern medicine, primarily used for diagnosing various cardiac arrhythmias that may not be captured during standard electrocardiogram (ECG) recordings. With advancements in technology, portable Holter monitors can now continuously record electrocardiographic data for extended periods, providing valuable insights into arrhythmic events. Aim of the Study: This study aims to evaluate the effectiveness of prolonged Holter monitoring in detecting atrial fibrillation (AF) and other arrhythmias in patients following ischemic stroke. We seek to establish the optimal duration of monitoring that maximizes detection rates while considering clinical feasibility and cost-effectiveness. Materials and Methods: We conducted a systematic review of recent literature, analyzing data from randomized clinical trials and observational studies that assessed the yield of AF detection through various durations of Holter monitoring. Key metrics included detection rates of AF and other relevant arrhythmias, along with patient outcomes related to therapeutic interventions initiated based on monitoring results. Conclusions: Prolonged Holter monitoring significantly enhances the detection of atrial fibrillation and other arrhythmias in stroke patients compared to standard 24-hour assessments. Extended monitoring durations, particularly those exceeding 48 hours, are recommended to optimize patient management and reduce the risk of recurrent strokes. Our findings underscore the need for integrating advanced monitoring techniques into clinical practice to improve diagnostic accuracy and patient outcomes.