Aim: The development of a multifunctional prosthetic and rehabilitation center with an innovative educational component for patients with limb amputations. Materials and Methods: The authors analyzed contemporary literature sources, including descriptions and discussions of the key aspects of developing a multifunctional prosthetic and rehabilitation center for patients with limb amputations. Conclusions: A modern multifunctional prosthetic and rehabilitation center with an innovative educational component implements a multimodal approach to habilitation and rehabilitation of patients with amputated limbs. This approach encompasses medical-therapeutic interventions, functional physical rehabilitation, psychosocial support, and a mandatory comprehensive educational preparation program for patients. The development of such multidisciplinary centers significantly expands the spectrum of opportunities for effective rehabilitation and subsequent social reintegration of patients into society. The strategic objectives of these centers correlate with global priorities of the healthcare system and align with the integrated medical care model paradigm, which organically combines primary and specialized levels of medical service provision. The strategic objectives of these centers align with the global healthcare priorities and correspond to the paradigm of an integrated healthcare model, which organically combines primary and specialized levels of medical service provision. Implementing a comprehensive approach that integrates accessible therapeutic and preventive services, high-tech rehabilitation methods, and preventive medical supervision enables the Center to not only improve individual health indicators and quality of life for patients with amputations but also achieve broader public health objectives, including reducing the economic burden on healthcare systems associated with suboptimal medical rehabilitation services for individuals with disabilities due to amputations.