Aim: To improve the results of treatment of patients with osteomyelitis on the background of traumatic disease. Materials and Methods: A retrospective evaluation of the treatment of 29 patients with chronic post-traumatic osteomyelitis of the bones of the lower extremities on the background of a traumatic disease. Results: As a result of the treatment, an acceleration of the dynamics of the wound process was observed in patients of the second group, which was manifested in a reduction in the healing time of fistulas. Radiologically, reparative changes and acceleration of bone regeneration were noted on the 22nd-23rd day after the injury, the formation of a primary bone callus in patients of the control group occurred on the 32nd-35th day after the injury. Conclusions: The use of methods for the prevention and treatment of osteomyelitic complications in long bone fractures, using high-intensity laser radiation against the background of regional intra-arterial infusions, with correction of the state of “chronic stress”, allows accelerating the dynamics of the wound process and bone regeneration, and achieving rapid restoration of working capacity in most patients.