Aim: To investigate the impact of adaptive football training sessions on the indicators of health-related quality of life, health status, and the cognitive domain of individuals with amputations. Materials and Methods: The research included 32 male service members and law enforcement officers who had suffered limb amputations as a result of blast and shrapnel injuries sustained during the war in Ukraine (2022-2025). Twenty-six participants had lower-limb amputations, and six had upper-limb amputations. Indicators of health-related quality of life and health status were assessed via the “SF-36 Health Survey”. Cognitive domain status was evaluated using the indicators of “Attention Distribution and Span” and “Attention Concentration and Sustainability”. Results: It was found that adaptive football training sessions contributed to a statistically significant improvement in the physical and mental components of health among individuals with amputations. The greatest positive changes were observed in social functioning (12.28 %), vitality (9.99 %), and physical functioning (9.77 %) indicators. A statistically significant improvement was also observed in cognitive indicators: attention distribution and span (15.03 %) and attention concentration and sustainability (3.26 %). At the same time, changes in pain intensity did not reach statistical significance. Conclusions: Adaptive football is an effective means of physical and sports rehabilitation for individuals with amputations, providing a comprehensive positive impact on indicators of health status, health-related quality of life, and cognitive domain. Regular training sessions help increase physical activity, improve psychological and emotional well-being, promote social adaptation, confirming the value of incorporating adaptive football into rehabilitation programs for people with amputations.