Aim: To conduct an analytical review of modern scientific publications and research on the development of new directions of interdisciplinary approaches to the problems of orthofascial harmonization of the face. Materials and Methods: .nalytical-synthetic theoretical methods of analysis of scientific research and registers of professional associations were used. The results of analysis were synthesized and interpreted in the conclusions. Information sources and time frame. Searches were run in PubMed/MEDLINE, Scopus, Web of Science Core Collection, SciELO and LILACS; official registers of professional bodies were consulted for normative documents (Conselho Federal de Odontologia; Ordem dos Médicos Dentistas). Coverage: 1 January 2000 to 1 September 2025 (last search: 1 September 2025). Conclusions: Orthofacial harmonisation is a promising direction that integrates minimally invasive cosmetic procedures into dentistry. Interest in orthofacial harmonization is driven by increasing patient demand. The advantages lie in the comprehensive restoration of the functionality and aesthetics of organs of the maxillofacial region, in the minimisation of the risks of medical interventions, and in socio-psychological comfort in the interaction between doctor and patient. The prospects for the development of orthofacial harmonisation include: conducting clinical trials, the validation of a scale for assessing the results of the application of orthofacial harmonization, improvement of ethical-legal foundations of physicians’ activity, standardization of educational-professional training programs for specialists, and the unification of medical protocols on orthofacial harmonization.