Aim:
Background: Renal cell carcinoma represents the most common type of kidney cancer with critical role of DNA repair mechanisms in carcinogenesis. Aims: investigate the association RAD18 Arg302Gln (rs373572) and OGG1 Ser326Cys (rs1052133) - with RCC susceptibility and histopathological features.

Material and methods:
Methodology: A case–control study was conducted using allele-specific PCR for genotyping.

Results:
Results: The cohort comprised cases with clear cell, chromophobe, and variant RCC subtypes. A significant link was found between OGG1 rs1052133 and RCC risk (p = 0.006), with the GG genotype being strongly linked to disease occurrence p=0.005. Haplotype analysis identified a significant association of the GC with RCC (p=0.013). LD analysis revealed a significant interaction between RAD18 and OGG1 loci (χ² = 9.214, p = 0.027), with an r- value of 0 in cases and 0.14 in controls. Histopathological correlations revealed that OGG1 rs1052133 genotypes showed a highly significant association with RCC p<0.001. RAD18 rs373572 genotypes were significantly closed link with tumor stage p=0.001. TNM classification exhibited a significant correlation with RAD18 genotypes p=0.017.

Conclusions:
Conclusion: A significant association between OGG1 rs1052133 and both RCC susceptibility and tumor histological subtype, proposed a potential role in disease pathogenesis. RAD18 rs373572 showed relevance to tumor stage and TNM classification, indicating a possible role in disease progression rather than initiation.