Aim: To determine the features of disturbances in the antioxidant-prooxidant balance of the liver in conditions of mechanical trauma of various localizations complicated by acute blood loss. Materials and Methods: Traumatic brain injury(TBI), blunt abdominal trauma (BAT), and skeletal trauma (ST) were modeled in mature male Wistar line rats under conditions of thiopental sodium anesthesia. Additionally, acute blood loss in the amount of 1,5 % of body weight was modeled in the traumatized rats. After 3, 7, 14, 21, and 28 days of the post-traumatic period, catalase activity and malondialdehyde content were determined in the liver homogenate extract, and the antioxidant-prooxidant index (API) was calculated based on their ratio. Results: Modeling mechanical traumas of different localizations, compared to the control, caused a shift in the antioxidant-prooxidant balance in the liver towards the predominance of prooxidant mechanisms. In the case of traumatic brain injury, the result was statistically significant starting from the 7-th day of the post-traumatic period, and for blunt abdominal trauma and skeletal trauma – starting from the 3-rd day. The greatest decrease in the antioxidant-prooxidant index at all times of the post-traumatic period was observed with blunt abdominal trauma. Complication of the modeled mechanical traumas with acute blood loss was accompanied by a deepening of metabolic disorders in the liver. In the case of traumatic brain injury, the liver API reached its minimum after 14 days of the post-traumatic period; for traumas of other localizations – already after 3 days. The amplitude of impairments at all times of the post-traumatic period was greater in the group of rats with blunt abdominal trauma. Conclusions: Modeling mechanical traumas of different localizations compared to the control is accompanied by a shift in the liver’s antioxidant-prooxidant balance towards the prevalence of prooxidant mechanisms, which is intensified by additional acute blood loss in the amount of 1,5 % of body weight. The largest disorders in the index are noted with blunt abdominal trauma.