Igf-1 in acne pathogenesis and inositol as possible adjuvant treatment of acne
1
UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE
2
TREATMENT AND DIAGNOSTIC CENTER “ASCLEPIUS”, UZHHOROD, UKRAINE
Publication date: 2026-05-29
Wiadomości Lekarskie 2026;(5):1081-1085
KEYWORDS
ABSTRACT
Aim: To provide a comprehensive review of acne pathogenesis and data regarding inositol efficacy in targeting IGF-1 pathway and decreasing IGF-1 levels and
find pathophysiological substantiation (rationale, reasoning) of inositol therapy feasibility in acne treatment.
Materials and Methods: Search of literature was performed on PubMed, Scopus, ResearchGate to identify scientific publications that aimed to research the role
of inositol in acne and IGF-1 in acne pathogenesis and treatment and were published between 1999 and 2024 yielding information about possible therapeutic
approach targeting IGF-1 induced increased sebum production. Peer-reviewed full-text articles, systematic reviews and evidence-based guidelines were included.
Conclusions: We provided a comprehensive review of acne pathogenesis and data regarding inositol efficacy in targeting IGF-1 pathway.
| eISSN: | 2719-342X |
| ISSN: | 0043-5147 |
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