Osteoblastic MG63 CELLS promoted by ATP shows apoptotic LDH release under guggulsterone exposure
1
DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE, UNIVERSITY OF KUFA, NAJAF, IRAQ
2
COLLEGE OF HEALTH AND MEDICAL TECHNIQUES, AL-FURAT AL-AWSAT TECHNICAL UNIVERSITY, KUFA, IRAQ
These authors had equal contribution to this work
Submission date: 2025-09-28
Final revision date: 2025-11-28
Acceptance date: 2025-12-11
Publication date: 2026-04-30
Corresponding author
Wiadomości Lekarskie 2026;(4):712-719
KEYWORDS
TOPICS
ABSTRACT
Aim:
The aim of this study is to identify the anticancer potential of guggulsterone on Mg63 cells
Material and methods:
ATP was administered to promotes growth was given to MG-63 human osteosarcoma cells that have osteoblastic features. Different amounts of guggulsterone were added to MG 63 cells, and their shape and rate of growth were studied. The amount of LDH in cells was measured to evaluate cell toxicity
Results:
The findings show that guggulsterone caused more changes in the shape of MG63 cells after they were exposed to it. With higher amounts of guggulsterone, cell growth slowed down significantly. This research talks about how guggulsterone might kill cells in osteoblasts. The results that were seen in this study were similar to what had been seen in other studies on different cell types
Conclusions:
Based on the results, we conclude that guggulsterone plays an important part in the changes that happen to the shape of cancer cells when they grow faster.
The aim of this study is to identify the anticancer potential of guggulsterone on Mg63 cells
Material and methods:
ATP was administered to promotes growth was given to MG-63 human osteosarcoma cells that have osteoblastic features. Different amounts of guggulsterone were added to MG 63 cells, and their shape and rate of growth were studied. The amount of LDH in cells was measured to evaluate cell toxicity
Results:
The findings show that guggulsterone caused more changes in the shape of MG63 cells after they were exposed to it. With higher amounts of guggulsterone, cell growth slowed down significantly. This research talks about how guggulsterone might kill cells in osteoblasts. The results that were seen in this study were similar to what had been seen in other studies on different cell types
Conclusions:
Based on the results, we conclude that guggulsterone plays an important part in the changes that happen to the shape of cancer cells when they grow faster.
| eISSN: | 2719-342X |
| ISSN: | 0043-5147 |
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