Pathogenetic aspects of the features of androgen deficiency state under the condition of experimental varicocele
1
laboratory of reproductive endocrinology, SI «V. Danilevsky Institute for endocrine pathology problems of NAMS of Ukraine», Kharkiv, Ukraine, Ukraine
2
Department of Social, Humanitarian and Biomedical Disciplines, PRIVATE ESTABLISHMENT OF HIGHER EDUCATION «KHARKIV INSTITUTE OF MEDICINE AND BIOMEDICAL SCIENCES», UKRAINE, Ukraine
3
laborotory of reproductive endocrinology, SI «V. DANILEVSKY INSTITUTE FOR ENDOCRINE PATHOLOGY PROBLEMS OF NAMS OF UKRAINE», KHARKIV, UKRAINE, Ukraine
4
Faculty of Biotechnology, State Biotechnological University, Ukraine
These authors had equal contribution to this work
Submission date: 2024-10-06
Final revision date: 2025-06-29
Acceptance date: 2025-08-28
Publication date: 2025-12-11
Corresponding author
Nataliia Mikhailovna Brechka
laboratory of reproductive endocrinology, SI «V. Danilevsky Institute for endocrine pathology problems of NAMS of Ukraine», Kharkiv, Ukraine, Alchevskikh, 10, 61002, Kharkiv, Ukraine
laboratory of reproductive endocrinology, SI «V. Danilevsky Institute for endocrine pathology problems of NAMS of Ukraine», Kharkiv, Ukraine, Alchevskikh, 10, 61002, Kharkiv, Ukraine
Wiadomości Lekarskie 2025;(10):1998-2007
KEYWORDS
TOPICS
ABSTRACT
Aim:
The aim of this article is to study of the main pathogenetic aspects of the features of androgen deficiency state under the condition of experimental varicocele caused by serotonin hydrochloride
Material and methods:
Simulation of serotonin testicular damage (experimental varicocele) is used to reproduce gonadal pathology. In the mechanism of the development of this gonadopathy was the vasoconstrictor effect of serotonin hydrochloride plays a leading role. Serotonin hydrochloride (Alfa Aesar®, USA) was administered for 14 days at a dose of 5 mg/kg of body weight (“pathology” group).
Results:
Experimental varicocele led to disturbance of structural elements of connective tissue (and the content of connective tissue components of glycosaminoglycans in the testes and chondroitin sulfates in the seminal plasma) as a leading link in the pathogenetic chain which promotes the formation of hormone dependent reproductive diseasess.
Conclusions:
Experimental varicocele on the background of the androgen deficiency state led to the disturbance of the morphofunctional state of the mitochondria of testicular cells, damage to the nuclear membrane, a decrease in the content of testosterone in the blood and fructose in the seminal vesicles; a decrease in the concentration and motility of spermatozoa.
The aim of this article is to study of the main pathogenetic aspects of the features of androgen deficiency state under the condition of experimental varicocele caused by serotonin hydrochloride
Material and methods:
Simulation of serotonin testicular damage (experimental varicocele) is used to reproduce gonadal pathology. In the mechanism of the development of this gonadopathy was the vasoconstrictor effect of serotonin hydrochloride plays a leading role. Serotonin hydrochloride (Alfa Aesar®, USA) was administered for 14 days at a dose of 5 mg/kg of body weight (“pathology” group).
Results:
Experimental varicocele led to disturbance of structural elements of connective tissue (and the content of connective tissue components of glycosaminoglycans in the testes and chondroitin sulfates in the seminal plasma) as a leading link in the pathogenetic chain which promotes the formation of hormone dependent reproductive diseasess.
Conclusions:
Experimental varicocele on the background of the androgen deficiency state led to the disturbance of the morphofunctional state of the mitochondria of testicular cells, damage to the nuclear membrane, a decrease in the content of testosterone in the blood and fructose in the seminal vesicles; a decrease in the concentration and motility of spermatozoa.
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| eISSN: | 2719-342X |
| ISSN: | 0043-5147 |
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