ABSTRACT Aim: The aim of our study was to assess the health-related quality of life of adolescents in the city of Myrhorod during the war in Ukraine. Materials and Methods: The study involved 102 adolescents (mean age - 14.5±1.6 years) from the city of Myrhorod, including 58 girls and 44 boys. To study the quality of life of adolescents, the KIDSCREEN - 52 methodology was used, which is most often used in most European countries and does not require adaptation, since it includes a universal and local element. Frequency analysis with extensive indicator calculation was used to analyze the survey responses. MS Office 2016 software package, namely MS Excel module, was used to process statistical information. Results: The results showed low and medium levels in such quality of life indicators as physical activity and health, psychological well-being, emotional state, autonomy, relationships with parents, social support and experiences of bullying. Sufficient levels were recorded in such quality of life indicators as financia resources, self-perception and school environment. Reduced quality of life among adolescents in relation to relationships with parents, emotional state and free time, as well as gender differences in self-perception and physical activity. Conclusions: This study allowed us to analyze ten key dimensions of HRQoL and develop practical recommendations for adolescents that cover the importance of regular physical activity, supporting psychological well-being, building healthy relationships with parents and peers, and improving self-educational and organizational skills for effective use of free time.